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Fig. 5 | BMC Complementary Medicine and Therapies

Fig. 5

From: Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

Fig. 5

Effect of TAA and/or (GA and/or Met) on histopathological examination of livers (H&E 100 μm). A photomicrograph of a section in the liver of a control animal, displaying normal central vein (CV) and normal hepatocytes (H) with intact sinusoids (S). B-A photomicrograph of a section in the liver of the TAA group, displaying widening of the central vein (CV), loss of cellular structure around the central vein (black arrow) and sinusoids oozing blood (S). C-A photomicrograph of a section in the liver of animals treated with TAA and GA, displaying a central vein filled with blood (CV), leukocyte infiltration around the central vein (LI) and hepatocytes with pyknotic nucleus (H). D-A photomicrograph of a section in the liver of animals treated with TAA and Met, displaying widening of central vein (CV) with detachment of endothelial lining of c.v (red arrow), leukocyte infiltration around the central vein (LI), and sinusoids oozing blood (black arrow). E-A photomicrograph of a section in the liver of animals treated with TAA (GA + Met), displaying nearly normal hepatic architecture with intact hepatocytes (H) radiated from an apparently normal central vein (CV), and apparently normal sinusoids(S) with numerous Kupffer cells (green arrow). (GA) gallic acid, (Met) metformin, (TAA) thioacetamide

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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