Fig. 3

Cytotoxicity effect of lactoferrin-loaded exosomes (exoLF). By evaluating the growth inhibition potency of exoLF on tumoral cells (MDA-MB 231 cell lines) and normal cells (MSCs), we detected 50% cell growth inhibition (IC50) on MDA-MB 231 cell lines at 1 mg/ml of exoLF concentration, compared to other concentrations. None of the 0.1, 1, 10, and 20 mg/ml exoLF could induce a cytotoxicity effect on MSCs. ns: not significant, **: P ≤ 0.001, ***: P ≤ 0.0001