Table 12 Quality of evidence based on GRADE approach
Certainty assessment | № of patients | Effect | Certainty | Importance | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
№ of | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Treatment | Control | Absolute | ||
study | (95% CI) | ||||||||||
TG | Randomized trials | Serious | Not serious | Not serious | Not serious | None | 362 | 339 | SMD 0.66 SD lower | ⨁⨁⨁◯ | important |
15 | (1.17 lower to 0.16 lower) | Moderate | |||||||||
TC | Randomized trials | Serious | Not serious | Not serious | Not serious | None | 320 | 297 | SMD 0.43 SD lower | ⨁⨁⨁◯ | important |
14 | (0.86 lower to 0.01 lower) | Moderate | |||||||||
LDL | Randomized trials | Serious | Not serious | Not serious | Not serious | None | 300 | 277 | SMD 0.44 SD lower | ⨁⨁⨁◯ | important |
13 | (0.88 lower to 0.01 lower) | Moderate | |||||||||
HDL | Randomized trials | Serious | Not serious | Not serious | Not serious | Publication bias strongly suspected | 362 | 339 | SMD 0.1 SD higher | ⨁⨁◯◯ | important |
15 | (0.28 lower to 0.48 higher) | Low | |||||||||
SBP | Randomized trials | Serious | Not serious | Not serious | Not serious | None | 206 | 217 | SMD 0.56 SD lower | ⨁⨁⨁◯ | important |
9 | (1.58 lower to 0.47 higher) | Moderate | |||||||||
DBP | Randomized trials | Serious | Not serious | Not serious | Not serious | None | 206 | 217 | SMD 1.33 SD lower | ⨁⨁⨁◯ | important |
9 | (2.14 lower to 0.53 lower) | Moderate | |||||||||