Table 2 IC-values, SR, and P-values of single and combined treatment with Sora and Que or Rsv in human colorectal cancer cell lines

A. Single and combined treatment with Sora and Que.

IC-values (µM)

SR

P-value

IC-values (µM)

SR

P-value

1. Sequential treatment with Sora and Que: Sora (24 h) followed by Que (48 h)

 a. Sora (0.25- 10 µM)

IC₆₀ = 0.57

N.A

0.337 vs. b

0.235 vs. c

IC₅₀ = 6.86

N.A

0.395 vs. b

0.682 vs. c

 b. Sora (0.25- 10 µM) + Que (60 µM)

IC₆₀ = 1.14

0.500

b

IC₅₀ = 9.43

0.728

b

 c. Sora (0.25- 10 µM) + Que (120 µM)

IC₆₀ = 2.00

0.300

c

IC₅₀ = 9.43

0.728

c

2. Inverted sequential treatment with Sora and Que: Que (24 h) followed by Sora (48 h)

 a. Sora (0.25- 10 µM)

IC₆₀ = 4.86

N.A

-

IC₅₀ = 6.86

N.A

0.006 vs. b

0.010 vs. c

 b. Sora (0.25- 10 µM) + Que (60 µM)

IC₆₀ = 3.43

1.420

0.353

N.D

N.D

b

 c. Sora (0.25- 10 µM) + Que (120 µM

IC₆₀ = 2.00

2.430

0.152

N.D

N.D

c

3. simultaneous treatment with Sora and Que:(72 h)

 a. Sora (0.25- 10 µM)

IC₈₀ = 4.00

N.A

-

IC₅₀ = 6.57

N.A

0.022 vs. b

0.189 vs. c

 b. Sora (0.25- 10 µM) + Que (60 µM)

IC₈₀ = 0.57

7.020

0.581

N.D

N.D

b

 c. Sora (0.25- 10 µM) + Que (120 µM

IC₈₀ = 0.86

4.650

0.882

10.00

0.66

c

B. Single and combined treatment with Sora and Rsv

IC-values (µM)

SR

P-value

IC-values (µM)

SR

P-value

1. Sequential treatment with Sora and Rsv: Sora (24 h) followed by Rsv (48 h)

 a. Sora (0.25- 10 µM)

IC₆₀ = 0.57

N.A

0.522 vs. b

IC₅₀ = 6.86

N.A

0.452 vs. b

0.831 vs. c

 b. Sora (0.25- 10 µM) + Rsv (40 µM)

IC₆₀ = 1.14

0.500

b

IC₅₀ = 9.71

0.71

b

 c. Sora (0.25- 10 µM) + Rsv (80 µM)

IC₆₀ = 1.70

0.340

0.883

IC₅₀ = 9.14

0.75

c

2. Inverted sequential treatment with Sora and Rsv: Rsv (24 h) followed by Sora (48 h)

 a. Sora (0.25- 10 µM)

IC₆₀ = 4.86

N.A

-

IC₅₀ = 6.57

N.A

0.003 vs. b

0.024 vs. c

 b. Sora (0.25- 10 µM) + Rsv (40 µM)

IC₆₀ = 0.86

5.650

0.001

N.D

N.D

b

 c. Sora (0.25- 10 µM) + Rsv (80 µM)

N.D

N.D

0.0001

N.D

N.D

c

3. simultaneous treatment with Sora and Rsv: (72 h)

 a. Sora (0.25- 10 µM)

IC₆₀ = 1.14

N.A

-

IC₆₀ = 7.71

N.A

0.044 vs. b

0.964 vs. c

 b. Sora (0.25- 10 µM) + Rsv (40 µM)

IC₆₀ = 0.57

2.00

0.238

N.D

N.D

b

 c. Sora (0.25- 10 µM) + Rsv (80 µM)

IC₆₀ = 0.57

2.00

0.401

IC₆₀ = 6.57

1.170

c