Fig. 9

Flow cytometric analysis of apoptosis in human colon cancer cell line SW1116 with Sora, Cur, or Que, and a combination of both. SW1116 was untreated (a), treated with Sora (5 µM) (b), Cur (200 µM)(c), Cur (400 µM) (d), and simultaneous combinations of Sora and Cur (5 + 200 µM) (e) or (5 + 400 µM) (f) or treated with Que (200 µM) (g), Que (400 µM) (h), and simultaneous combinations of Sora (5 µM) and Que (200 or 400 µM) (i, j) for 72 h. B1, percentage of necrotic cells; B2, percentage of late apoptotic cells; B3, percentage of viable cells; and B4, percentage of early apoptotic cells. Sora, sorafenib; Cur, curcumin; UT, untreated; PI, propidium iodide; FITC, fluorescein isothiocyanate; CRC, colorectal cancer