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Table 1 Chemical identification numbers (CID) and summary of the mode of action of compounds 1–11

From: Antimicrobial, antioxidant, and sun protection potential of the isolated compounds from Spermacoce princeae (K. Schum)

Compound

Molecular formula

CID

Mode of action

1

C15H10O7

5280343

Compounds 1, 2 and 3 form complexes with proteins through nonspecific forces such as hydrogen donation [52, 55]

2

C27H30O15

5318767

3

C27H30O16

5280805

4

C6H12O6

892

Chelation of ferric ions and suppression of hydroxyl radicals [56]

5

C18H24O12

11968867

Suppresses NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages [57]

6

C16H32O2

985

Regulates cell proliferation by induced retinoic acid receptors [58]

7

C29H50O

222284

Reduces the phosphorylation of nuclear factor-kB p65 by binding U937 cells to TNF-a-stimulated HAEC [59]

8

C29H48O

5280794

Bonds with glucocorticoid receptors to induce the production of prostaglandins and other pro-inflammatory mediators [60]

9

C28H48O

173183

A secondary massager in the colon (HT29), breast (MCF7) or prostate (LNCap) cancer cells that activates ceramide metabolism [61]

10

C30H48O3

64945

Stimulates the nuclear translocation of glucocorticoid receptors [62]

11

C35H60O6

296119

Reduces the phosphorylation of nuclear factor-kB p65 by binding U937 cells to TNF-a-stimulated HAEC [59]