Table 4 The activity evaluation of constituents from XCHD in HCoV-229E induced CPE reduction assay
Compound | Pubchem ID | TC50 a | IC50 b | SIc | Source | Structure |
|---|---|---|---|---|---|---|
Isoliquiritigenin | 638278 | 12.93 | 1.85 | 6.98 | Chaihu; Zhigancao |
|
Eleutheroside E | 71312557 |  > 50 | 50 |  > 1.0 | Renshen |
|
Ginsenoside Rb1 | 9898279 |  > 50 | 50 |  > 1.0 | Renshen |
|
Kaempferide | 5281666 | 28.87 | 16.67 | 1.73 | Chaihu; Renshen |
|
Citric acid | 311 |  > 50 | 50 |  > 1.0 | Chaihu; Renshen; Dazao |
|
Citropten | 2775 | 28.87 | 16.67 | 1.73 | Chaihu; Shengjiang |
|
6-Shogaol | 5281794 | 3.21 | 1.44 | 2.23 | Banxia; Shengjiang |
|
( +)-Catechin Hydrate | 107957 |  > 50 | 38.8 |  > 1.29 | Dazao |
|
Betulinic acid | 64,971 | 16.67 | 0.36 | 46.77 | Dazao |
|
(20R)-Ginsenoside Rh1 | 21599923 |  > 50 | 9.62 |  > 5.20 | Renshen |
|
Methyl salicylate | 4133 |  > 50 | 34.67 |  > 1.44 | Chaihu |
|
Scopoletin | 5280460 |  > 50 | 50 |  > 1.0 | Chaihu; Dazao |
|
Chrysin | 5281607 | 34.67 | 4.63 | 7.49 | Huangqin |
|
Schisandrin B | 108130 | 28.87 | 4.31 | 6.7 | Renshen |
|
Ginsenoside Rg3 | 9918693 |  > 50 | 16.67 |  > 3.0 | Renshen |
|
L-(-)-Fucose | 3034656 |  > 50 | 28.87 |  > 1.73 | Renshen |
|
Paeonol | 11092 |  > 50 | 50 |  > 1.0 | Banxia; Renshen |
|
Ribavirind | 37542 |  > 100 | 2.2 ± 0.87 |  > 49.44 ± 19.59 | - |
|
