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Table 3 List of the 37 potential HCoVs host targets of XCHD

From: Systems pharmacology dissection of pharmacological mechanisms of Xiaochaihu decoction against human coronavirus

Target gene symbol

Full name

MCL1

BCL2 family apoptosis regulator

BCL2L1

BCL2 like 1

BCL2A1

BCL2 related protein A1

BCL2

BCL2, apoptosis regulator

CXCL10

C-X-C motif chemokine ligand 10

CLEC4M

C-type lectin domain family 4 member M

CD209

CD209 molecule

FKBP1A

FK506 binding protein 1A

JUN

Jun proto-oncogene, AP-1 transcription factor subunit

ANPEP

alanyl aminopeptidase, membrane

ACE2

angiotensin I converting enzyme 2

CTSS

cathepsin S

CAV1

caveolin 1

CHEK2

checkpoint kinase 2

COX2

cytochrome coxidase subunit II

DPP4

dipeptidyl peptidase 4

XPO1

exportin 1

FURIN

furin, paired basic amino acid cleaving enzyme

G6PD

glucose-6-phosphate dehydrogenase

GBF1

golgi brefeldin A resistant guanine nucleotide exchange factor 1

HGS

hepatocyte growth factor-regulated tyrosine kinase substrate

IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

IRF3

interferon regulatory factor 3

IL6

interleukin 6

KPNA2

karyopherin subunit alpha 2

PPIA

peptidylprolyl isomerase A

PPIG

peptidylprolyl isomerase G

PTBP1

polypyrimidine tract binding protein 1

PHB

prohibitin

PSMA2

proteasome subunit alpha 2

PPP1CA

protein phosphatase 1 catalytic subunit alpha

SERPING1

serpin family G member 1

STAT3

signal transducer and activator of transcription 3

SFTPD

surfactant protein D

TERF1

telomeric repeat binding factor 1

TGFB1

transforming growth factor beta 1

UBE2I

ubiquitin conjugating enzyme E2 I