Table 2 Herbs in XCHD and their corresponding HCoV-associated host targets
Herb | Target gene symbol |
|---|---|
Chaihu | ACE2, ANPEP, BCL2, BCL2A1, BCL2L1, CAV1, CD209, CHEK2, CLEC4M, CTSS, CXCL10, DPP4, FKBP1A, FURIN, G6PD, GBF1, HGS, IKBKB, IL6, IRF3, JUN, KPNA2, MCL1, PPIA, PPP1CA, PTBP1, SERPING1, SFTPD, STAT3, TGFB1, XPO1 |
Huangqin | ACE2, BCL2, BCL2L1, CAV1, CHEK2, IKBKB, IL6, JUN, MCL1, STAT3, TGFB1 |
Banxia | ANPEP, BCL2, BCL2A1, BCL2L1, CHEK2, DPP4, FURIN, G6PD, GBF1, HGS, IKBKB, IL6, IRF3, JUN, KPNA2, MCL1, PPIA, PPIG, PPP1CA, PTBP1, STAT3, TGFB1 |
Shengjiang | BCL2, BCL2L1, CXCL10, DPP4, FKBP1A, FURIN, G6PD, IKBKB, IL6, IRF3, JUN, MCL1, PPIA, PSMA2, STAT3, TGFB1 |
Renshen | ACE2, ANPEP, BCL2, CD209, CLEC4M, DPP4, FKBP1A, FURIN, IKBKB, IL6, JUN, MCL1, PPIA, SFTPD, STAT3, TERF1, TGFB1, UBE2I |
Zhigancao | IKBKB |
Dazao | ACE2, ANPEP, BCL2, BCL2A1, BCL2L1, CAV1, CD209, CHEK2, CLEC4M, COX2, CXCL10, DPP4, FKBP1A, FURIN, GBF1, HGS, IKBKB, IL6, IRF3, JUN, KPNA2, MCL1, PHB, PPIA, PPIG, PPP1CA, PTBP1, SFTPD, STAT3, TGFB1 |