Table 2 Relative abundance (%) of blank, model, HCQ, FRZ-H, FRZ-M, and FRZ-L groups (n = 8 per group)

Bacteroidaceae (family)

5.13 ± 0.68

32.29 ± 3.81^**

30.68 ± 4.33

24.70 ± 2.41

27.94 ± 1.94

21.52 ± 3.29^#

Muribaculaceae (family)

32.30 ± 2.81

18.87 ± 2.83^**

13.07 ± 2.49

15.90 ± 3.12

17.24 ± 3.02

20.87 ± 3.61

Lachnospiraceae (family)

9.03 ± 2.08

16.59 ± 3.82

24.66 ± 4.84

21.44 ± 2.60

18.81 ± 1.94

19.83 ± 3.35

Helicobacteraceae (family)

1.68 ± 0.57

9.09 ± 1.90^**

10.18 ± 2.85

14.04 ± 2.67

10.73 ± 1.83

11.99 ± 2.63

Rikenellaceae (family)

29.72 ± 2.41

3.12 ± 0.44

2.11 ± 0.45

3.38 ± 0.35

4.96 ± 1.26

5.78 ± 1.42

Tannerellaceae (family)

1.32 ± 0.18

6.13 ± 0.54^**

4.72 ± 0.97

4.94 ± 0.65

5.59 ± 0.90

5.46 ± 1.04

Marinifilaceae (family)

4.32 ± 0.36

0.92 ± 0.27

1.06 ± 0.34

1.43 ± 0.32

1.08 ± 0.24

1.10 ± 0.44

Ruminococcaceae (family)

0.98 ± 0.17

1.41 ± 0.23

2.07 ± 0.38

1.74 ± 0.28

1.43 ± 0.12

2.06 ± 0.30

Prevotellaceae (family)

2.36 ± 0.37

0.55 ± 0.19^**

0.43 ± 0.11

0.74 ± 0.11

0.54 ± 0.11

0.40 ± 0.08

Clostridiales_vadinBB60_group (family)

1.20 ± 0.19

1.59 ± 0.27

1.04 ± 0.16

1.63 ± 0.46

1.19 ± 0.25

1.45 ± 0.39

Bacteroides (genus)

5.13 ± 0.68

32.29 ± 3.81^**

30.68 ± 4.33

24.70 ± 2.41

27.94 ± 1.94

20.52 ± 3.28^#

Muribaculaceae (genus)

32.22 ± 2.80

18.75 ± 2.82^**

12.93 ± 2.46

15.82 ± 3.10

17.12 ± 3.00

20.74 ± 3.60

Helicobacter (genus)

1.68 ± 0.57

9.09 ± 1.90^*

10.18 ± 2.85

14.04 ± 2.67

10.73 ± 1.83

11.99 ± 2.63

Rikenellaceae_RC9_gut_group (genus)

20.01 ± 1.89

1.61 ± 0.28^**

1.14 ± 0.55

1.07 ± 0.17

3.09 ± 1.21

3.55 ± 1.37

Parabacteroides (genus)

1.31 ± 0.18

5.98 ± 0.53^**

4.62 ± 0.95

4.86 ± 0.64

5.50 ± 0.90

5.36 ± 1.03

Alistipes (genus)

8.80 ± 0.56

1.29 ± 0.22^**

0.43 ± 0.16^##

1.21 ± 0.09

1.28 ± 0.27

1.40 ± 0.09

Lachnospiraceae_UCG-001 (genus)

0.41 ± 0.22

1.02 ± 0.31

1.65 ± 0.59

3.52 ± 0.70^##

1.79 ± 0.92

1.60 ± 0.38

Odoribacter (genus)

4.29 ± 0.37

0.92 ± 0.27^**

1.06 ± 0.34

1.42 ± 0.32

1.08 ± 0.24

1.10 ± 0.44

[Eubacterium]_fissicatena_group (genus)

0.04 ± 0.02

1.63 ± 0.31^**

0.69 ± 0.11^#

1.36 ± 0.49

1.32 ± 0.29

1.18 ± 0.40

Blautia (genus)

0.50 ± 0.20

0.74 ± 0.25

1.74 ± 0.55

0.81 ± 0.11

0.70 ± 0.16

0.5 ± 0.11