Fig. 6

Heat map (A), scatterplot (B), and Pearson correlation analysis (C) of significantly differential metabolites enriched KEGG pathways regulated by FRZ-H for 10 weeks. A In the heat map, the x axis indicates the sample name, and the y axis indicates the differential metabolite. Low and high abundance of metabolites is indicated in blue and red, respectively. B The numbers of metabolites are indicated by the dot size in the scatterplot. C Pearson correlation analysis between fecal metabolites and microbial genera after of high dose of FRZ administration for 10 weeks; ^* P < 0.05, ^** P < 0.01 and ^*** P < 0.001