2-phenylacetamide Separated from the seed of Lepidium apetalum Willd. inhibited renal fibrosis via MAPK pathway mediated RAAS and oxidative stress in SHR Rats

Table 3 Influence of PA on inflammatory factors and oxidative damage factor in renal of SHR rats

Groups	COX2 (ng/mL)	IL-1 (pg/mL)	ET-1 (pg/mL)	MDA (nmol/mL)	E-selectin (ng/mL)	MCP-1 (pg/mL)
WKY	378.43 ± 24.31	659.19 ± 34.05	2.15 ± 0.52	61.53 ± 2.11	34.90 ± 2.63	2.5 ± 0.49
SHR	685.76 ± 100.95^**	1148.3 ± 222.08^**	7.11 ± 1.17^**	72.97 ± 3.33^**	43.85 ± 1.37^**	6.89 ± 1.01^**
SHR + HCTZ	422.36 ± 63.29^##	677.76 ± 61.24^##	1.8 ± 0.51^##	64.23 ± 3.63^#	41.67 ± 0.54	3.85 ± 1.03^##
SHR + 15	373.16 ± 11.49^##	1142.4 ± 177.19	2.09 ± 0.58^##	69.33 ± 6.1	42.99 ± 2.78	3.65 ± 0.96^##
SHR + 30	336.36 ± 93.19^##	646.93 ± 43.66^##	1.81 ± 0.66^##	66.71 ± 5.76	39.52 ± 0.75^#	3.04 ± 0.87^##
SHR + 45	205.28 ± 22.6^##	468.16 ± 60.59^##	2.46 ± 1.36^##	64.54 ± 3.36^#	38.48 ± 3.44^#	2.88 ± 0.50^##

Data are expressed as mean ± SD, n = 8 per group. ^* P < 0.05, ^** P < 0.01 vs. WKY group; ^# P < 0.05, ^## P < 0.01 vs. SHR group

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