Fig. 4

Differentially expressed genes between hepatocellular carcinoma and normal liver tissues. (A) Up-regulated KEGG pathway enrichment in LIHC. (B) Down-regulated KEGG pathway enrichment in LIHC, pathways overlapped with the corosolic acid targets were shown in red. (C) Venn diagram showed that the protein expression levels of P4HA2, CCDC137, and NDRG1 were down-regulated after corosolic acid treatment while their genes were up-regulated in hepatocellular carcinoma tissues. (D) Venn diagram showed that the protein expression levels of SDC4 was up-regulated after corosolic acid treatment while its gene was down-regulated in hepatocellular carcinoma tissues. (E) Comparison of mRNA Expression of P4HA2, CCDC137, NDRG1 and SDC4 in Hepatocellular Carcinoma and Normal Liver Tissues Using GEPIA Dataset, Including 369 cases of hepatocellular carcinoma and 160 cases of normal liver tissue