Chemical composition, cholinesterase, and α-glucosidase inhibitory activity of the essential oils of some Iranian native Salvia species

Table 3 Enzyme inhibitory activity of Salvia spp. EOs at the concentration of 500 μg/mL^a

Plants EO	α-glucosidase (inhibition %)	AChE (inhibition %)	BChE (inhibition %)	SI^c
S. sharifii	86.9 ± 0.1^****	7.8 ± 0.3^****	42.0 ± 0.3^****	5.38
S. sclarea	33.4 ± 0.5^****	1.5 ± 0.1^****	32.8 ± 0.1^****	21.86
S. verticillata	85.5 ± 0.7^****	1.1 ± 0.1^****	25.3 ± 0.6^****	23
S. syriaca	33.7 ± 0.3^****	15.8 ± 0.5^****	52.1 ± 0.4^****	3.29
S. santolinifolia	88.4 ± 0.7^*	2.7 ± 0.2^****	44.1 ± 0.4^****	16.33
S. reuterana	89.7 ± 0.2^ns	1.6 ± 0.1^****	27.8 ± 0.9^****	17.37
S. multicaulis	85.9 ± 0.8^****	0.5 ± 0.1^****	44.1 ± 0.5^****	88.2
S. spinosa	90.5 ± 0.1	1.4 ± 0.2^****	25.5 ± 0.6^****	18.21
S. palaestina	87.6 ± 1.2^****	2.1 ± 0.1^****	7.0 ± 0.1^****	3.33
S. virgata	89.7 ± 0.6^ns	1.8 ± 0.1^****	25.5 ± 0.7^****	14.16
S. hypoleuca	22.7 ± 0.7^****	2.8 ± 0.2^****	11.3 ± 0.4^****	4.03
S. mirzayanii (Shiraz)	28.5 ± 1.0^****	40.6 ± 0.5	72.7 ± 0.1	1.79
S. mirzayanii (Jahrom)	NA^b	30.8 ± 0.6^****	64.8 ± 0.4^****	2.10
S. mirzayanii (Darab)	25.5 ± 0.4^****	23.9 ± 0.4^****	63.0 ± 0.3^****	2.64
Acarbose	50.2 ± 1.1	-	-	-
Donepezil	-	89.9 ± 0.12	83.0 ± 0.1	-

^aReported as (Mean ± SD)
^bNot Active
^cSI: Selectivity Index = BChE (% inhibition)/AChE (% inhibition)
Mean comparison of each EO was compared with the value obtained from the most potent EO in each biological activity through one-way ANOVA test followed by Tukey post-hoc multiple comparisons (****p < 0.0001, *p < 0.05, and ns = not significant)

ISSN: 2662-7671