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Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats

Fig. 6

The morphological changes of synapses in the CA1, CA3 of hippocampal by Golgi staining. A Golgi staining of the whole brain, and each rat slice at the level of the CA1, CA3 region (box) (10x, 30x). B A CA3 neuron with the proximal portion of its apical dendrite (arrow), Sholl rings are placed at 20 um diameter intervals (200x). C Representative graphs of synapses in the CA1, CA3 of hippocampal neurons stained by Golgi (200x). D The longest dendrite length, total length of dendrites, the number of dendritic intersections, density of dendritic spines in each group of CA1 region. E The longest dendrite length, total length of dendrites, the number of dendritic intersections, density of dendritic spines in each group of CA3 region. Data are expressed as means ± SEM, n = 3 in each group. *P < 0.05; ** P < 0.01 vs. the control group; # P < 0.05; ## P < 0.01 vs. the CUMS group

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