Fig. 4

Differential expression analysis of miRNAs, lncRNAs, circRNAs and mRNAs by RNA-seq. A Volcano plot, MA plot of DEmiRNAs, DElncRNAs, DEcircRNAs and DEmRNAs expression profiles between XYS-treated CUMS rats and CUMS rats. B Number of up- and down-regulated ncRNAS and mRNAs. C The differential expression of ncRNAs and mRNAs were validated by qRT-PCR. D The GO, KEGG enrichment analysis of DElncRNA, DEmRNAs, DEmiRNAs, DEcircRNAs. In the GO analysis, the ontology contained biological process(BP), cellular component(CC), and molecular function(MF). n = 3 in each group. The abscissa indicates the number of genes, the ordinate indicates the GO term, and the color of the column indicates the corrected p value. In the KEGG analysis, the size of the dots represents the number of genes annotated in the pathway, and the color of the dots represents the corrected p value of the hypergeometric test