Fig. 1

A schematic diagram showing the experimental design. After 1 week of habituation, rats were subjected to CUMS procedure for four weeks. Except for the control group, the rats in the other groups were subjected to CUMS for 4 weeks and treated with different drugs. Fluoxetine (5.4 mg/kg/day) or Xiaoyaosan (2.224 g/kg/day) were administered i.g once a day. The K252a or DMSO were intrahippocampal microinjected on the 7th, 14th, 21th, 28th day respectively, then OFT, SPT, FST were implemented. Then, the rats were sacrificed for further detection