Catechin, epicatechin, curcumin, garlic, pomegranate peel and neem extracts of Indian origin showed enhanced anti-inflammatory potential in human primary acute and chronic wound derived fibroblasts by decreasing TGF-β and TNF-α expression

Table 1 Details of anti-inflammatory protein marker, test phytoextracts, parameters analysed and concentration used in the study

Sl. No	Name of the commercial phytoextract	Botanical name	Part of the plant used	Major phytoactive compound	Sample code	Cells	Concentration used	Anti-inflammatory protein marker
1	Catechin extract	Camellia sinensis (L.) Kuntze	Leaves	Catechin (83%)	CE	AWF & CWF	100 μg/ml	TGF-β & TNF-α
2	Epicatechin extract	Acacia catechu (L.f) Willd	Heartwood	Epicatechin (16.6%)	E	AWF & CWF	100 μg/ml	TGF-β & TNF-α
3	Curcumin extract	Curcuma longa (L.)	Rhizome	Curcuminoids (95.4%)	CU	AWF & CWF	100 μg/ml	TGF-β & TNF-α
4	Garlic extract	Allium sativum (L.)	Bulb	Saponins (NLT 5%)	G	AWF & CWF	100 μg/ml	TGF-β & TNF-α
5	Pomegranate peel extract	Punica granatum (L.)	Peel	Polyphenols (NLT 40%)	P	AWF & CWF	100 μg/ml	TGF-β & TNF-α
6	Neem extract	Azadirachta indica A. Juss	Leaves	Bitters (NLT 2%)	N	AWF & CWF	100 μg/ml	TGF-β & TNF-α

All the phytoextracts showed absence of Coliforms, E. coli, Salmonella, Pseudomonas aeruginosa, Staphylococcus aureus. The presence of toxic heavy metals such as lead, cadmium, arsenic and mercury were NMT 5 ppm. Loss of sample on drying was NMT 5%

ISSN: 2662-7671