Organs | Pathogenesis | CMC-AL (mg/kg body weight) | |||||
---|---|---|---|---|---|---|---|
1,000 | 3,000 | 5,000 | |||||
Male | Female | Male | Female | Male | Female | ||
Brain | Diffuse degeneration of the cerebral white matter | 0 | 0 | 0 | 0 | 0 | 0 |
Heart | Myocardial cell necrosis | 0 | 0 | 0 | 0 | 0 | 0 |
Lung | Macrophage accumulation | 0 | 0 | 4 (+) | 2 (+) | 5 (+) | 3 (+) |
Foreign body granuloma | 0 | 0 | 0 | 0 | 0 | 0 | |
Liver | Spotty necrosis | 0 | 0 | 3 (+) | 2 (+) | 4 (+) | 3 (+) |
Kidney | Renal interstitial inflammation | 0 | 0 | 0 | 2 (+) | 4 (+) | 2 (+) |
Stomach | Ulcer | 0 | 0 | 0 | 0 | 0 | 0 |
Spleen | Lymphoid hyperplasia | 0 | 0 | 0 | 0 | 0 | 0 |
Adrenal grand | Cortical hyperplasia | 0 | 0 | 0 | 0 | 0 | 0 |
Bladder | Cystitis and lesions | 0 | 0 | 0 | 0 | 0 | 0 |
Prostate | Prostatitis | 0 | 0 | 0 | 0 | 0 | 0 |
Testis | Testicular atrophy | 0 | 0 | 0 | 0 | 1 (+) | 0 |
Epididymis | No mature sperm | 0 | 0 | 0 | 0 | 0 | 0 |
Uterus | Epithelial necrosis | 0 | 0 | 0 | 1 (+) | 0 | 1 (+) |