Table 4 Serum biochemistry parameters of male and female rats in the chronic toxicity evaluation of the CMC-AL in comparison with control. Data are presented as median (range with 95%CI) of twenty rats
Parameters | Control | CMC-AL (mg/kg bw.) | ||||||
|---|---|---|---|---|---|---|---|---|
1,000 | 3,000 | 5,000 | ||||||
Male | Female | Male | Female | Male | Female | Male | Female | |
Total protein (g/dl) * | 7.4 (7.2–8.1) | 8.4 (8.1–9.0) | 8.3 (7.5–8.9)* | 7.6 (7.3–8.6)* | 8.1 (7.7–9.0)* | 7.3 (6.8–8.2)* | 7.9 (7.5–9.0)* | 7.2 (6.9–8.1)* |
AST (U/l) * | 119.9 (108.6–140.2) | 222.0 (214.4–238.6) | 125.2 (117.8–143.8) | 230.23 (209.7–257.4) | 145.3 (138.6–170.2)* | 219.5 (208.4–240.3) | 150.7 (140.9–178.5)* | 228.6 (210.6–245.0) |
ALT (U/l) * | 89.7 (76.2–102.5) | 103.5 (85.4–125.6) | 92.4 (79.7–110.3) | 99.3 (87.9–119.8) | 111.6 (102.6–124.7)* | 108.2 (99.5–122.6) | 117.8 (108.9–130.6)* | 107.1 (97.2–116.4) |
Cholesterol (mg/dl) * | 162.6 (145.3–186.7) | 137.0 (119.5–157.6) | 165.7.0 (140.8–198.6) | 140.1 (121.7–169.5) | 168.5 (156.1–189.5) | 169.6 (154.2–203.9)* | 164.2 (143.8–195.6) | 185.3 (157.6–217.8)* |
BUN (mg/dl) * | 18.5 (17.4–19.2) | 19.9 (19.3–20.6) | 18.2 (17.8–19.1) | 19.4 (19.1–20.7) | 19.0 (18.8–20.7) * | 19.7 (19.2–20.6) | 20.4 (19.1–21.3) * | 19.5 (18.8–20.5) |
Creatinine (mg/dl) | 0.5 (0.42–0.57) | 0.4 (0.35–0.46) | 0.5 (0.41–0.56) | 0.4 (0.36–0.50) | 0.5 (0.45–0.62) | 0.4 (0.32–0.51) | 0.5 (0.44–0.58) | 0.4 (0.32–0.49) |
Albumin (g/dl) * | 4.4 (4.0–5.1) | 5.9 (5.5–6.3) | 4.3 (4.0–4.9) | 5.8 (5.3–6.2) | 4.5 (4.3–5.1) | 5.9 (5.5–7.2) | 6.7 (6.3–7.9)* | 6.0 (5.7–6.7) |
Globulin (g/dl) | 2.8 (2.45–2.96) | 1.9 (1.35–1.98) | 2.7 (2.38–2.92) | 2.0 (1.67–2.08) | 2.5 (2.23–2.86) | 1.8 (1.67–2.03) | 2.9 (2.59–3.13) | 2.0 (1.75–2.11) |
ALP (U/l) | 75.0 (68.43–81.95) | 43.0 (40.04–46.74) | 69.0 (67.76–80.24) | 45.5 (41.82–49.35) | 72.0 (67.47–82.03) | 48.1 (41.62–50.71) | 74.0 (69.68–82.35) | 47.7 (44.93–49.05) |
Glucose (mg/dl) * | 389.4 (342.3–501.0) | 271.3 (224.5–357.8) | 455.2 (397.2–556.4)* | 299.7 (267.4–402.8)* | 442.8 (370.6–564.3)* | 324.3 (247.6–407.8)* | 492.4 (375.6–614.7)* | 348.9 (297.6–426.5)* |
Uric acid (mg/dl) | 13.1 (12.74–14.21) | 8.5 (8.16–8.93) | 13.4 (13.06–14.31) | 8.2 (7.98–8.67) | 13.5 (13.22–13.99) | 8.0 (7.75–8.46) | 13.7 (13.31–14.25) | 8.4 (7.98–8.65) |
Triglycerides (mg/dl) * | 210.6 (176.5–243.7) | 244.1 (202.7–289.6) | 215.4 (198.7–257.8) | 239.5 (227.6–295.7) | 217.6 (186.2–236.9) | 251.7 (186.3–299.4) | 204.1 (190.6–245.7) | 304.5 (257.4–412.3)* |