Table 2 Serum biochemistry parameters of male and female rats in the subchronic toxicity evaluation of the CMC-AL in comparison with control. Data are presented as median (range with 95% CI) of five rats

Total protein (g/dl) *

9.25 (7.87–10.73)

7.2 (6.88–7.68)

8.2 (7.66–8.54)*

7.9 (7.67–8.13)

8.5 (8.27–9.01)

7.9 (7.43–8.53)

8.4 (7.96–8.76)*

7.8 (7.21–8.45)

AST (U/l) *

131.0 (123.93–139.67)

98.0 (93.81–101.39)

119.0 (92.75–147.25)

159 (150.6–164.6)*

112.0 (80.58–128.62)

97.0 (85.99–106.01)

98.0 (87.25–127.57)

99.0 (91.35–103.05)

ALT (U/l) *

87.0 (60.83–100.77)

44.0 (32.81–49.19)

62.0 (48.55–70.25)*

62.0 (56.09–66.72)*

52.0 (42.49–59.91)*

37.0 (33.68–39.12)

60.0 (43.88–88.12)

29.0 (23.45–42.15)

Cholesterol (mg/dl) *

116.0 (92.0–149.57)

95.0 (89.78–98.62)

90.0 (83.71–97.49)*

99.0 (92.11–120.3)

88.0 (64.9–103.09)*

101.0 (89.6–118.4)

98.0 (81.1–140.1)

123 (116.5–130.3)*

BUN (mg/dl)

21.9 (19.89–25.43)

20.6 (19.67–21.37)

19.6 (16.92–23.96)

22.6 (19.75–25.17)

20.5 (14.66–23.86)

19.6 (13.81–23.58)

19.3 (16.39–22.53)

22.45 (14.36–30.63)

Creatinine (mg/dl)

0.4 (0.31–0.49)

0.4 (0.36–0.48)

0.4 (0.32–0.44)

0.4 (0.37–0.51)

0.4 (0.27–0.48)

0.4 (0.31–0.49)

0.4 (0.25–0.47)

0.4 (0.36–0.48)

Albumin (g/dl)

6.7 (5.87–7.37)

6.2 (6.06–6.72)

6.0 (5.6–6.59)

6.3 (6.03–6.65)

6.2 (6.07–6.48)

6.8 (6.07–7.21)

6.1 (5.64–6.72)

6.9 (5.91–7.49)

Globulin (g/dl)

2.6 (1.85–3.03)

1.5 (1.27–1.73)

2.0 (1.67–2.61)

1.7 (1.58–1.82)

2.0 (1.71–2.74)

1.6 (1.42–1.70)

2.0 (1.74–2.54)

1.7 (1.52–1.80)

ALP (U/l)

68.0 (49.68–85.52)

34.0 (27.81–38.19)

62.0 (56.9–73.5)

40.0 (22.03–47.57)

58.0 (29.61–77.99)

27.0 (22.15–33.45)

62.0 (50.58–73.02)

36.0 (25.77–41.43)

Glucose (mg/dl)

445.0 (309.0–653.0)

116.0 (73.6–173.6)

488.0 (352.3–582.5)

119.0 (105.9–138.5)

447.0 (430.4–487.2)

199.0(102.1–270.3)

303.0 (255.7–413.1)

181.0 (88.09–246.3)

Uric acid (mg/dl)

12.3 (10.70–15.8)

6.6 (5.64–7.76)

11.4 (10.14–12.69)

6.9 (5.61–7.55)

12.3 (11.61–12.98)

7.3 (5.44–8.84)

10.9 (9.57–12.35)

6.4 (5.01–10.75)

Triglycerides (mg/dl)

167.0 (130.7–220.5)

77.0 (64.76–93.24)

136.0 (119.44–174.16)

81.0 (70.02–88.38)

196.0 (116.24–277.36)

73.0 (62.96–85.04)

112.0 (65.82–184.18)

73.0 (50.88–100.72)