Table 1 Hematological parameters of male and female rats in the subchronic toxicity evaluation of the CMC-AL in comparison with control. Data are presented as median (range with 95% CI) of five rats

RBCs (× 10 ⁶ /µl) *

10.20 (9.58–10.45)

9.06 (8.93–9.15)

9.65 (9.41–10.07)

8.55 (8.28–9.06)

10.00 (9.35–10.45)

8.3 (7.87–8.96)*

9.38 (8.84–10.25)

8.96 (8.45–9.08)

HCT (%) *

59.7 (58.6–61.3)

55.1 (54.01–56.87)

58.3 (56.8–61.0)

53.8 (53.2–54.8)*

58.7 (57.0–60.0)

53.4 (52.08–54.47)*

58.9 (56.2–60.8)

55.2 (53.64–56.28)

Hemoglobin (g/dl)

17.7 (17.07–18.29)

16.5 (16.24–16.96)

17.7 (16.32–18.32)

16.7 (16.24–16.93)

17.5 (16.64–18.32)

16.3 (15.82–16.82)

17.1 (16.57–17.75)

16.7 (16.37–17.7)

MCV(fl or µm³)

61.9 (58.99–63.17)

61.2 (59.82–63.42)

59.9 (57.95–63.05)

62.4 (61.32–63.76)

60.3 (57.24–63.19)

63.2 (61.51–64.01)

59.4 (58.57–60.11)

62.4 (61.36–63.92)

MCH (pg)

17.9 (17.57–18.63)

18.4 (17.84 -19.12)

17.9 (16.94–18.66)

19.1 (18.31–19.5)

17.8 (17.23–18.26)

19.3 (18.33–19.73)

17.9 (17.24–18.25)

19.4 (18.41–20.0)

MCHC (g/dl)

30.1 (29.26–31.14)

29.9 (29.58–30.34)

29.6 (28.22–30.46)

30.5 (30.04 -30.73)

29.9 (28.83–30.53)

30.1 (29.92–30.56)

29.8 (28.81–30.79)

30.5 (29.86–31.49)

WBCs (× 10³/µl)

8.96 (7.87–10.21)

6.67 (4.97–7.57)

7.78 (5.76–9.98)

6.38 (5.57–7.02)

8.86 (7.43–9.99)

6.64 (3.68–10.31)

7.54 (4.23–9.57)

7.95 (4.65–9.85)

Platelets (× 10 ³ /µl) *

1390 (1214–1559.5)

1034 (947.5–1122.1)

1189.0 (1058.8–1530.0)

936 (815.1–1016.9)

1414.0(1202.0–1721.9)

1134 (908.8–1369.2)

1567.0(1374.6–1722.5)

1249 (1051.2–1425.9)*

RDW (%)

23.4 (21.04–25.28)

16.9 (16.37–18.51)

23.9 (22.95–25.05)

16.8 (16.32–17.08)

23.4 (22.74–24.18)

16.9 (16.24–18.4)

23.3 (21.03–25.33)

16.8 (16.29–17.51)

PDW (%)

22.0 (20.55–23.33)

19.4 (19.2–19.6)

22.2 (21.4–23.7)

19.3 (18.37–19.99)

21.4 (21.05 -22.27)

19.7 (18.67–20.21)

20.9 (20.78–21.18)

19.5 (18.98–19.69)

MPV (fl)

12.1 (11.28–12.64)

8.3 (8.12–8.40)

12.5 (11.8–13.12)

7.9(6.98–8.75)

12.5 (12.10–12.94)

8.7 (8.23–9.05)

11.9 (11.36–12.4)

8.9 (7.88–9.91)

PCT (%)

1.61 (1.37–1.89)

0.92 (0.85–0.98)

1.89 (1.48–2.47)

0.85 (0.68–0.97)

1.86 (1.37–2.28)

0.98 (0.85–1.07)

1.33 (1.15–1.64)

0.98 (0.74–1.27)

Neutrophils (%)

10.1 (7.8–13.1)

9.5 (5.7–11.1)

9.3 (7.5 -13.2)

4.2 (2.4–7.0)

8.8 (5.7–13.8)

5.6 (0.8–11.4)

6.5 (0.4–12.8)

4.5 (0.3–12.2)

Lymphocytes (%)

83.2 (77.9–90.5)

85.7 (81.0–89.2)

82.2 (77.9–85.4)

88.5 (79.8–94.9)

83.8 (72.1–91.0)

89.4 (77.6–97.6)

70.3 (47.8 -89.8)

90.4 (80.1–96.1)

Basophils (%)

1.1 (0.3–2.2)

1.3 (1.3–1.3)

1.5 (0.9–1.8)

1.3 (1.3–1.3)

2.1 (0.4–6.6)

1.3 (0.7–1.9)

1.6 (0.3–5.5)

1.0 (0.5–1.6)

Eosinophils (%) *

0.7 (0.2–1.3)

0.7 (0.02–2.6)

1.2 (0.8–2.3)

1.1 (0.4–3.9)

1.2 (0.2–3.4)

0.6 (0.3–3.7)

12.5 (2.6 -18.8)*

0.8 (0.2–2.6)

Monocytes (%) *

4.5 (0.16–6.17)

4.7 (1.1–9.5)

2.56 (0.27–10.34)

2.5 (2.1–10.2)

3.27 (1.01–5.77)

2.2 (0.1–6.3)

10.0 (6.46–11.4)*

2.0 (0.1–6.1)