Fig. 4

Primary CCA tumors and lung metastases at autopsy of the CCA (CL-6)-xenografted nude mice following treatment with CMC-AL at high-, medium-, and low-dose levels (5000, 3000 and 1000 mg/kg body weight, respectively), cisplatin (reference control: 40 mg/kg body weight) and untreated control (A). Quantification of the percentage of lung metastatic area is shown in the right (B). *P = 0.01 and **P = 0.001