Fig. 1

Identification of potential compounds and targets in KJG against depression. (a) The volcano distributions of differentially expressed genes (cut-off of pvalue = 0.05). The abscissa represents the log2 fold change value, and the ordinate represents the adjusted P-value (-log10 P-value). The green and red dots represent up-regulated and down-regulated genes in depression, respectively. (b) Venn map: The target genes of depression were obtained by combining the five databases. (c) Venn Diagram. The interaction of KJG targets and depression targets. (d) Compound-target network: The blue rectangles represent overlapping genes between KJG and depression; the light green, dark blue, dark green, magenta, red, and navy blue ovals represent the compounds from Renshen, Chaihu, Chishao, Fuling, and Gancao, respectively. (e) PPI network: (1) The interactions among the common targets from the STRING database; (2) The first filtered network was extracted from (1) by the EC, DC, LAC, CC, BC, and NC medium; (3) The second filtered network was extracted from (2) by the EC, DC, LAC, CC, BC, and NC medium