Table 1 Results of antiplasmodial screening against Pf3D7 and PfDd2 and selectivity on Raw cell lines

Extracts and fractions

 DEM

9.62 ± 0.48

6.32 ± 0.00

0.65

 > 250

 > 26

 > 40

 DEF

3.10 ± 0.09

3.56 ± 0.03

1.14

 > 250

 > 81

 > 70

 DEH

 > 100

23.39 ± 0.30

-

 > 250

-

 > 11

 DEC

1.82 ± 0.72

5.17 ± 0.10

2.84

 > 250

 > 137

 > 48

 DEA

3.43 ± 0.01

1.44 ± 0.21

0.41

 > 250

 > 73

 > 174

 DEN

3.83 ± 0.17

3.62 ± 0.05

0.94

ND

-

-

 DFH

2.70 ± 0.64

2.98 ± 0.22

1.31

 > 250

 > 93

 > 84

 DFC

16.92 ± 0.76

10.37 ± 0.19

0.61

 > 250

 > 15

 > 24

 DFA

3.84 ± 0.22

8.79 ± 0.10

2.28

 > 250

65

 > 28

 DFN

10.36 ± 0.98

8.47 ± 0.09

0.81

 > 250

 > 24

 > 30

 DFM

8.72 ± 1.28

4.56 ± 0.19

0.52

 > 250

 > 29

 > 55

Compounds

 Griseoxanthone C (2)

 > 25

 > 25

-

 > 100

-

-

 3,3'-di-O-methylellargic acid (3)

1.17 ± 0.04

1.36 ± 0.14

1.16

 > 100

 > 85

 > 74

 3,3′,4-tri-O-methylellagic acid (4)

 > 25

0.63 ± 0.27

-

 > 100

-

159

 3,3″-di-O-methylellagic acid 4-O-(3″-galloyl)-β-D-xylopyranoside (5)

1.86 ± 0.18

1.76 ± 0.14

1.12

 > 100

 > 87

 > 64

 3,4-dihydroxybenzoic acid (6)

 > 25

17.09 ± 0.06

-

 > 100

-

 > 6

 Confluentic acid (7)

 > 25

 > 25

-

 > 100

-

-

 Glyceryl-1-tetracosanoate (8)

 > 25

 > 25

-

 > 100

-

-

 Auranthiamide acetate (9)

 > 25

 > 25

-

 > 100

-

-

 Ethyl gallate (10)

1.15 ± 0.10

2.86 ± 0.07

2.48

 > 100

 > 87

 > 35

 β-amyrinacetate (11)

 > 25

 > 25

-

 > 100

-

-

 β-amyrin (12)

 > 25

 > 25

-

ND

-

-

 3-oxo-lanosta-7,24-Z-dien-26-oid acid (13)

 > 25

14.21 ± 0.11

-

 > 100

-

 > 7

 Mixture of β- and α- amyrin (14)

 > 25

3.14 ± 0.09

-

 > 100

-

 > 32

 Artemisinin (nM)

14.66 ± 0.11

18.90 ± 0.13

0.12

-

-

-

 Chloroquine (nM)

4.36 ± 0.53

133 ± 0.16

30.5

-

-

-