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Table 6 Skeletal malformations found in the offspring of females treated with the ethanolic extract of S. lachnostachys (EESl)

From: The ethanolic extract of Salvia lachnostachys Benth is not maternotoxic, does not alter reproductive performance, but has teratogenic potential

Skeletal Malformation

Experimental groups (mg/kg)

Parameters

 

Control

EESl 100

EESl 1000

Analyzed fetuses

 

45

44

55

Normal Fetuses

 

18

11

20

Members

 Anterior phalanges

Absence

0

2

0

Reduced number

4

2

2

 Posterior phalanges

Absence

0

2

0

Reduced number

1

2

3

 Freq.Malf

 

5

8

5

 % M.F

 

11.11

18.18

9.10

 MTC

Reduced number

0

1

0

 MTT

Reduced number

0

1

0

 Freq.Malf

 

0

2

0

 %M.F

 

0

4.55

0

Sternum

 Sternum Bones

O.R. Last Center Sternal

19

22

33

Absence of the Last Sternal Center

1

6

3

 Absence

 

0

1

0

 Freq.Malf

 

20

29

36

 %M.F

 

44.44

65.90*

65.45*

Cranium

 Nasal

R.O

0

3

4

 Parietal

R.O

0

3

3

 Interparietal

R.O

0

3

3

 Supraoccipital

R.O

0

1

3

 Volmer

R.O

3

8

0

 Palate

R.O

1

5

1

 Basisphenoid

Absence

0

1

0

 Hamate

Absence

0

1

0

 Frontal

R.O

0

1

4

 Freq.Malf

 

4

26*

18*

 % M.F

 

8.89

59.09*

32.73*

  1. Legend: MTC metacarpal, MTT metatarsal, R.O Reduced Ossification, Freq.Malf Frequency of Malformations, % F.M— the percentage of fetuses with malformation
  2. *Statistical difference (Statistical test: Chi-square; p < 0.05)