Fig. 1

Experiment schedule. After a 7-day adaptation period, rats underwent OFT and SPT to exclude significant different individuals. Rats were exposed to CUMS modeling except for the control group. The daily BW and weekly food intake were monitored, and FBG was monitored every two weeks. After 6 weeks of CUMS modeling, rats in each group underwent OGTT, OFT, SPT, and FST. The rats were sacrificed and tissues were collected to detect the corresponding indicators. BW, body weight; FBG, fasting blood glucose; OGTT, oral glucose tolerance test; OFT, open field test; SPT, sucrose preference test; FST, forced swimming test; CUMS, chronic unpredictable mild stress