The neuroprotective effects of the combined extract of mulberry fruit and mulberry leaf against hydrogen peroxide-induced cytotoxicity in SH-SY5Y Cells

Table 3 The effect of the combined extract of mulberry fruit and mulberry leaf on oxidative stress markers in SH-SY5Y cell toxicity induced by hydrogen peroxide

Treatment groups	MDA (ng/mg protein)	CAT (units/mg protein)	SOD (units/mg protein)	GSH-Px (units/mg protein)
Naïve control	16.98 ± 0.96	44.08 ± 1.04	18.03 ± 1.74	24.76 ± 1.60
Hydrogen peroxide + vehicle	37.66 ± 4.35^aaa	27.38 ± 4.03^a	11.24 ± 0.84^aa	15.87 ± 1.79^aa
Hydrogen peroxide + MFML low dose	22.57 ± 2.21^**	36.74 ± 4.43	16.89 ± 1.34^*	22.38 ± 0.95^*
Hydrogen peroxide + MFML high dose	26.01 ± 1.56^*	37.20 ± 7.98	12.32 ± 0.85^a	22.21 ± 1.09^*

Data are presented as mean ± SEM. ^{a, aa, aaa}p < 0.05, 0.01 and 0.001, respectively; compared to naïve control, ^{*, **}p < 0.05 and 0.01, respectively; compared to SH-SY5Y cells treated with hydrogen peroxide, and which had received the vehicle. MFML low dose and MFML high dose: the combined extract of mulberry fruit and mulberry leaf at doses of 62.5 and 125 μg/mL, respectively

ISSN: 2662-7671