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Table 3 Degree of core regulatory genes analyzed by Cytoscape

From: Centipeda minima active components and mechanisms in lung cancer

Name

Symbol

Degree

Average Shortest PathLength

Betweenness Centrality

Closeness Centrality

Neighborhood Connectivity

Cellular tumor antigen p53

TP53

59

1

0.0722608505365032

1

30.2203389830508

RAC-alpha serine/threonine-protein kinase

AKT1

53

1.10169491525423

0.0315358277834266

0.907692307692307

32.4528301886792

Myc proto-oncogene protein

MYC

52

1.11864406779661

0.0255695601596003

0.893939393939394

32.6153846153846

Caspase-3

CASP3

50

1.15254237288135

0.0208417737179668

0.867647058823529

33.38

Epidermal growth factor receptor

EGFR

50

1.15254237288135

0.0227701783764299

0.867647058823529

33.38

G1/S-specific cyclin-D1

CCND1

49

1.16949152542372

0.021544091177951

0.855072463768116

32.938775510204

Vascular endothelial growth factor A

VEGFA

49

1.16949152542372

0.022790927250528

0.855072463768116

33.734693877551

Transcription factor AP-1

JUN

49

1.16949152542372

0.0205966593849399

0.855072463768116

33.7551020408163

Estrogen receptor

ESR1

49

1.16949152542372

0.0261671699202626

0.855072463768116

32.7551020408163

Mitogen-activated protein kinase 8

MAPK8

49

1.16949152542372

0.0181275332954268

0.855072463768116

33.7959183673469

Mitogen-activated protein kinase 1

MAPK1

48

1.1864406779661

0.0218192038686717

0.842857142857142

33.75

Receptor tyrosine-protein kinase erbB-2

ERBB2

45

1.23728813559322

0.0156141252299837

0.808219178082191

34.0666666666666

Pro-epidermal growth factor

EGF

44

1.25423728813559

0.0122804258465005

0.797297297297297

35.5681818181818

Prostaglandin G/H synthase 2

PTGS2

44

1.25423728813559

0.0125590212737923

0.797297297297297

35.4090909090909

Interleukin-8

CXCL8

42

1.28813559322033

0.0141048839673417

0.776315789473684

35.8571428571428

Tumor necrosis factor

TNF

42

1.28813559322033

0.00833145827093525

0.776315789473684

36.2380952380952

Matrix metalloproteinase-9

MMP9

41

1.30508474576271

0.00947791951541008

0.766233766233766

36.4878048780487

Bcl-2-like protein 1

BCL2L1

38

1.35593220338983

0.00798927862460732

0.7375

36.6052631578947

Androgen receptor

AR

37

1.3728813559322

0.010351431218464

0.728395061728395

36.081081081081

72 kDa type IV collagenase

MMP2

37

1.3728813559322

0.0062354852353676

0.728395061728395

38

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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