Fig. 1

Evaluation the model of AS induced by high fat diet. A Body weight of mice at 1, 4, 8 and 12 weeks. *P<0.05, ** P<0.01. B Plasma total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), ox-LDL levels (n = 12). *P<0.05, ** P<0.01. C HE staining of aortic root. Scale bar, 200 μm. The picture on the right is four times larger than the one on the left. D Frozen sections of aortic root were stained with Oil Red O. Scale bar, 200 μm. The picture on the right is four times larger than the one on the left. E-F The expression of NLRP3, NF-кB, Caspase-1 and IL-18 were detected by Western Blot (n = 3). *P<0.05, ** P<0.01. G The expression levels of NLRP3, NF-кB, Caspase-1 and IL-18 were detected by RT-PCR (n = 3). *P<0.05, ** P<0.01