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Table 5 Biochemical profile of Female rats treated with the aqueous extract of O. lamiifolium

From: Sub-chronic toxicity of the aqueous leaf extract of Ocimum lamiifolium Hochst. ex Benth on biochemical parameters and histopathology of liver and kidney in rats: in vivo and in- silico toxicity studies

Tests

Group

Group I 200 mg/ kg

Group II 400 mg/ kg

Group III 600 mg/ kg

Group IV Control

ALT (U/L)

54.2 ± 7.3

63.0 ± 4.0

78.7 ± 4.7a

54.4 ± 13.7

AST (U/L)

160.1 ± 8.7

164.2 ± 1.2

201.0 ± 4.1a

160.9 ± 8.4

ALP (U/L)

105.0 ± 4.6

107.2 ± 6.5

161.3 ± 8.2a

101.6 ± 4.1

Urea (mg/dL)

50.1 ± 2.3

54.3 ± 6.8

71.2 ± 10.0a

49.9 ± 4.6

Creatinine (mg/dL)

0.3 ± 0.0

0.4 ± 0.0

0.4 ± 0.0

0.3 ± 0.1

Albumin (g/dL)

3.7 ± 0.1

3.3 ± 0.2

3.4 ± 0.2

3.8.0 ± 0.3

Total protein (g/dL)

4.6 ± 0.5

4.4 ± 0.1

4.4 ± 0.1

4.9 ± 0.5

Total cholesterol (mg/dL)

68.6 ± 3.5

69.5 ± 5.8

69.7 ± 5.7

72.8 ± 8.4

Glucose (mg/dL)

101.5 ± 7.8

102.2 ± 8.2

81.0 ± 12.0b

120.0 ± 15.0

  1. Results are expressed as mean ± SMD. For all p < 0.05, One-Way ANOVA. ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase
  2. a significant difference with groups I and  IV
  3. b significantly different from the control group (Dunnett test)