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Fig. 5 | BMC Complementary Medicine and Therapies

Fig. 5

From: Forsythiaside A ameliorates sepsis-induced acute kidney injury via anti-inflammation and antiapoptotic effects by regulating endoplasmic reticulum stress

Fig. 5

A Activity pocket of GRP78 binding with Forsythiaside A. B The active site of GRP78 binding with Forsythiaside A was composed of amino acids residues Asp-178, Asn-177, Phe-176, Tyr-175, Arg-181, Thr-247, Ala-174, Ala-246, Val-244, Phe-242, Glu-243. C The interaction between Forsythiaside A with the activity cavity of GRP78. D In the binding pocket of GRP78, three hydrogen bonds with amino acids Arg-181、Val-244、Thr-247. Forsythiaside A formed hydrophobic contacts with two amino acids residues (Ala-174, Ala-246) in the active pocket of GRP78

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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