Analysis of the potential biological mechanisms of Danyu Gukang Pill against osteonecrosis of the femoral head based on network pharmacology

Table 2 DGP-ONFH common targets

Number	Protein Name	Gene Symbol	Gene ID	Degree
1	Vascular endothelial growth factor A	VEGFA	ENSP00000478570	18
2	Interleukin-6	IL6	ENSP00000385675	18
3	Tumor necrosis factor	TNF	ENSP00000398698	17
4	Peroxisome proliferator activated receptor gamma	PPARG	ENSP00000287820	17
5	Interleukin-10	IL10	ENSP00000412237	16
6	Cellular tumor antigen p53	TP53	ENSP00000269305	16
7	Matrix metalloproteinase-9	MMP9	ENSP00000361405	16
8	Nitric oxide synthase, endothelial	NOS3	ENSP00000297494	15
9	Hypoxia-inducible factor 1-alpha	HIF1A	ENSP00000437955	15
10	Plasminogen activator inhibitor 1	SERPINE1	ENSP00000223095	14
11	Transforming growth factor beta-1	TGFB1	ENSP00000221930	14
12	72 kDa type IV collagenase	MMP2	ENSP00000219070	13
13	Phosphatase and tensin homolog	PTEN	ENSP00000361021	13
14	Insulin-like growth factor-binding protein 3	IGFBP3	ENSP00000370473	12
15	Transcription factor E2F2	F2	ENSP00000308541	11
16	Nuclear factor erythroid 2-related factor 2	NFE2L2	ENSP00000380252	10
17	Apolipoprotein B-100	APOB	ENSP00000233242	9
18	Nuclear factor of activated T-cells, cytoplasmic 1	NFATC1	ENSP00000389377	8
19	Cytochrome P450 3A4	CYP3A4	ENSP00000337915	6

ISSN: 2662-7671