Fig. 7

Matrix heatmap showing the correlation coefficient matrix of significantly different proteins expressing significantly different metabolites (A) (C). r was identified between −1 and + 1. The correlation coefficient (r) for proteins and metabolites is indicated using colors. While r > 0 indicates a positive correlation and is represented in red, r < 0 indicates a negative correlation and is represented in blue. Darker colors indicate stronger correlations. Hierarchical clustering heatmap showing Pearson’s correlation analysis of differential proteins and metabolites (B) (D). Each row indicates a significantly different metabolite, whereas each column indicates a significantly different protein. The correlation analysis network between GSK/OP and OP/SHAM for significantly different proteins and metabolites (E) (F)