Table 1 Antimalarial activity against P. falciparum and the cytotoxicity of compounds from M. siamensis

Lupeol (1)

18.78 ± 3.45^a,b

> 80

29.27 ± 1.47^a,b

4,5-Dihydroxy-3-methoxylxanthone (2)

20.96 ± 3.56^a,b

> 80

> 80

4-Hydroxyxanthone (3)

68.55 ± 2.54^a,b

48.13 ± 1.68 ^a,b

46.12 ± 1.66 ^a,b

1,7-Dihydroxyxanthone (4)

41.67 ± 2.23^a,b

7.90 ± 0.90

13.27 ± 1.12 ^a,b

Mixture of β-sitosterol and stigmasterol (5)

45.00 ± 3.51^a,b

> 80

> 80

Mammea A/AA cyclo D (6)

45.62 ± 3.12^a,b

> 80

> 80

Mammea A/AA cyclo F (7)

49.89 ± 0.42^a,b

> 80

> 80

1,6-Dihydroxyxanthone (8)

47.94 ± 5.16^a,b

> 80

> 80

1-Hydroxy-5,6,7-trimethoxyxanthone (9)

9.57 ± 1.59 ^a,b

> 80

> 80

3,4,5-Trihydroxyxanthone (10)

15.48 ± 2.63^a,b

> 80

> 80

5-Hydroxy-1-methoxyxanthone (11)

29.32 ± 4.44^a,b

> 80

> 80

2-Hydroxyxanthone (12)

74.97 ± 0.88 ^a,b

> 80

> 80

1,5-Dihydroxy-6-methoxyxanthone (13)

22.27 ± 1.67^a,b

> 80

30.54 ± 1.49 ^a,b

Chloroquine*

103.2 ± 4.50

ND

ND

Artesunate*

0.53 ± 0.04

ND

ND

Doxorubicin

ND

1.46 ± 0.16

1.11 ± 0.05