Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

Table 3 Administration protocols of curcuminoids and rescue medications for patients of included studies

Studies	Dose (mg/time)	Frequency (time/day)	Daily dose ^a (mg/day)	Total dose ^b (g)	Rescue medications
Kuptniratsaikul V 2009 [56]	500	4	2000	84
Kuptniratsaikul V 2014 [57]	500	3	1500	42	Tramadol
Nakagawa Y 2014 [61]	90	2	180	10.08	Celecoxib
Panahi Y 2014 et al. [62]	500	3	1500	63	Naproxen
Srivastava S 2016 [65]	500	1	500	60	Diclofenac
Haroyan A 2018 [66]	500	3	1500	126
Gupte PA 2019 [67]	80	2	160	14.4
Panda SK 2018 [58]	500	1	500	30	Paracetamol
Herotin Y 2019 a [68]	93.34	2	186.68	33.6	Paracetamol / NSAIDs
Herotin Y 2019 b [68]	140.01	2	280.02	50.4	Paracetamol / NSAIDs
Shep D 2019 [59]	500	3	1500	42	Paracetamol
Wang Z 2020 [69]	500	2	1000	84	Paracetamol
Atabaki M 2020 [70]	80	1	80	7.2	Diclofenac
Hashemzadeh K 2020 [71]	40	2	80	3.36
Singhal S 2021 [60]	500	2	1000	42
Lopresti L 2022 [72]	500	2	1000	56

^a The daily dose of curcuminoids is equal to the product of the dose and frequency
^b The total dose of curcuminoids is equal to the product of the daily dose and follow-up duration

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