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Table 2 Effect of SAA on the coagulation function of DIC induced by LPS

From: Salvianolic acid A alleviates lipopolysaccharide-induced disseminated intravascular coagulation by inhibiting complement activation

Sample

R(min)

K(min)

Angle(°)

MA(mm)

CI

Control

2.21 ± 0.31a

1.11 ± 0.21a

74.39 ± 2.81a

70.02 ± 1.44a

4.568 ± 0.63a

LPS

3.29 ± 0.67b

2.95 ± 1.31b

56.679 ± 9.92b

49.91 ± 7.47b

-0.65 ± 0.75b

LPS + SAA

(40 mg/kg)

2.52 ± 0.52a

1.59 ± 0.58a

67.55 ± 6.03a

61.48 ± 6.03c

2.62 ± 1.68c

  1. 40 mg/kg SAA was administered by i.p. injection 1 h after, and 15 mg/kg LPS was administered by intravenous infusion. 3 h after, blood was obtained, and the coagulation function was tested with thromboelastometry. Data were presented as the mean ± SD. n = 9 in the Control group, n = 11 in the LPS group, and n = 9 in the LPS + SAA (40 mg/kg) group. Statistical analysis used were ANOVA (P<0.05), letters marked between different groups, if one is the same, the difference is not significant; if they are all different, the difference is significant