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Table 4 Histological grading of lymph node metastases [28]

From: Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model

Grading

Pathological features

score

Grade 0

Without metastasis

0

Grade I

There are piles of tumor cells only in the marginal sinus of lymph nodes, forming small metastases, and sometimes mitotic figure is seen

1

Grade II

There are obvious metastases both in the marginal and central sinus of lymph nodes

2

Grade III

Lymph nodes are mostly filled with tumor cells and common lesions can be observed in metastases

3

Grade IV

More than one lymph node has metastases, forming extensive metastases

4