Antimalarial activity of solvent fractions of a leaf of Eucalyptus globulus labill against Plasmodium berghei infected mice

Table 6 Effects of E. globulus leaf fractions on body weight and temperature against P.berghei infected mice in Rane’s test

Treatments	Bodyweight at D3(g)	Bodyweight at D7 (g)	% Change in body weight	Rectal temperature at D3 (°C)	Rectal temperature at D7 (°C)	% change in rectal temperature
2%tween 80 (10 ml/kg)	24.33 ± 0.71	21.25 ± 0.44	−12.55 ± 1.02	36.07 ± 0.29	33.15 ± 0.42	−8.09 ± 0.80
CQ (25 mg/kg)	25.33 ± 1.17	25.33 ± 0.84	0.34 ± 2.12^a3	35.80 ± 0.51	36.23 ± 0.25	1.27 ± 0.99^a3
CF (mg/kg) 100	27.00 ± 1.13	25.43 ± 1.03	−5.76 ± 0.67	36.48 ± 0.33	34.42 ± 0.20	−5.64 ± 0.65^b3
200	24.33 ± 0.80	23.67 ± 0.99	−2.85 ± 1.35^a2	36.35 ± 0.32	35.50 ± 0.37	−2.34 ± 0.30^a3
400	26.10 ± 0.56	25.83 ± 0.87	−1.12 ± 1.70^a3	36.45 ± 0.44	35.96 ± 0.33	−1.32 ± 0.72^a3
EAF (mg/kg)100	27.13 ± 0.91	25.27 ± 0.87	−6.88 ± 0.79^b1	36.13 ± 0.49	34.35 ± 0.58	−4.96 ± 0.35^b3
200	25.33 ± 0.92	24.38 ± 1.27	−4.00 ± 1.71^a2	36.02 ± 0.51	35.77 ± 0.31	−0.65 ± 0.80^a3
400	24.33 ± 0.80	25.12 ± 0.73	3.33 ± 1.44^a3	36.35 ± 0.55	36.38 ± 0.28	0.18 ± 1.32^a3
DW (10 ml/kg)	26.67 ± 1.02	24.30 ± 1.12	−8.99 ± 0.93	36.03 ± 0.42	33.18 ± 0.49	−7.92 ± 0.56
CQ (25 mg/kg)	25.33 ± 1.17	25.33 ± 0.84	0.34 ± 2.12^a3	35.80 ± 0.51	36.23 ± 0.25	1.27 ± 0.99^a3
AF (mg/kg) 100	25.67 ± 0.56	24.02 ± 0.79	−6.53 ± 1.17	36.17 ± 0.39	33.85 ± 0.42	−6.41 ± 0.67^b3
200	26.10 ± 1.48	25.32 ± 1.28	−2.77 ± 1.92	35.90 ± 0.35	35.27 ± 0.22	−1.73 ± 1.01^a3
400	27.00 ± 0.37	26.95 ± 0.55	−0.17 ± 1.75^a2	36.12 ± 0.32	35.93 ± 0.31	−0.49 ± 0.88^a3

Data are expressed as mean ± SEM.
CF Chloroform fraction, EAF Ethyl acetate fraction, DW Distilled water, AF Aqueous fraction, CQ Chloroquine
¹p < 0.05
²p < 0.01, p < 0.001
^acompared to negative controls
^bcompared to chloroquine

ISSN: 2662-7671