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Table 3 Dynamic change of body weight, liver weight, and serum biochemical indices of mice fed with HFD

From: Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1/AMPK signaling pathway

Time

4W

8W

12W

16W

Group

C

M

C

M

C

M

C

M

Body weight

23.73±0.93

30.93±

1.10**

27.67±

3.28

33.68±

1.08*

31±

2.26

38.8±

0.70*

31.8±

0.92

49.6±

1.09***

Liver weight

1.03±

0.07

0.75±

0.06

1.18±

0.16

1.20±

0.03

1.20±

0.01

1.30±

0.04

1.16±

0.11

1.64±

0.17***

Serum ALT

33.0±

3.0

32.17±

3.06

34.0±

2.29

29.17±

0.76

33.5±

11.63

35.67±5.49

29.0±

16.26

99.0±

10.04**

Serum AST

141.3±25.76

155.8±

46.2

164.0±

3.78

153.0±

40.3

162.7±

2.75

175.3±6.29

157.0±3.54

198.3±

24.06

Serum

TG

0.82±

0.23

0.75±

0.18

1.93±

0.28

1.55±

0.49

1.00±

0.22

1.18±

0.21

1.43±

0.60

0.88±

0.15

Serum

TC

1.90±

0.15

3.12±

0.25

2.60±

0.23

5.58±

0.08***

2.72±

0.40

5.63±

0.43***

3.28±

0.46

6.28±

0.84***

Serum HDL-c

1.87±

0.21

3.10±

0.23

2.52±

0.28

5.52±

0.24***

2.68±

0.43

5.60±

0.56***

3.58±

0.46

6.70±

0.69***

Serum LDL-c

0.23±

0.15

0.43±

0.15

0.12±

0.03

0.67±

0.15*

0.23±

0.06

0.85±

0.13

0.30±

0.14

1.15±

0.30**

  1. Data are expressed as mean±SD, n=3 per group, ***P < 0.001, **P < 0.01 compared to the control group