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Table 2 The potential targets of PLP in allergy

From: Network pharmacology-based analysis and experimental in vitro validation on the mechanism of Paeonia lactiflora Pall. in the treatment for type I allergy

 

Target name

Gene Symbol

1

androgen receptor

AR

2

progesterone receptor

PGR

3

vascular endothelial growth factor a

VEGFA

4

glutathione s-transferase mu 1

GSTM1

5

transient receptor potential cation channel subfamily v member 1

TRPV1

6

arachidonate 5-lipoxygenase

ALOX5

7

catalase

CAT

8

plasminogen

PLG

9

thyroid peroxidase

TPO

10

tumor necrosis factor

TNF

11

myeloperoxidase

MPO

12

aryl hydrocarbon receptor

AHR

13

potassium voltage-gated channel subfamily h member 2

KCNH2

14

5-hydroxytryptamine receptor 3a

HTR3A

15

mitogen-activated protein kinase 14

MAPK14

16

cathepsin d

CTSD

17

solute carrier family 22 member 5

SLC22A5

18

mitogen-activated protein kinase 1

MAPK1

19

intercellular adhesion molecule 1

ICAM1

20

tyrosinase

TYR

21

c-reactive protein

CRP

22

insulin

INS

23

glucagon

GCG

24

cholecystokinin

CCK

25

cholesteryl ester transfer protein

CETP

26

peptide yy

PYY

27

nuclear receptor subfamily 1 group i member 3

NR1I3

28

hemeoxygenase 1

HMOX1

29

glutathione s-transferase mu 2

GSTM2

30

lysozyme

LYZ

31

nuclear receptor coactivator 2

NCOA2

32

fatty acid synthase

FASN

33

aldo-ketoreductase family 1 member c1

AKR1C1

34

tyrosine aminotransferase

TAT

35

nuclear receptor coactivator 1

NCOA1

36

nadph oxidase 5

NOX5

37

apolipoprotein d

APOD

38

hyaluronan synthase 2

HAS2

39

microsomal glutathione s-transferase 1

MGST1

40

rhodopsin

RHO

41

transient receptor potential cation channel subfamily v member 3

TRPV3

42

dual oxidase 2

DUOX2

43

mitogen-activated protein kinase 10

MAPK10

44

ablinteractor 1

ABI1

45

lipoprotein lipase

LPL

46

sterol o-acyltransferase 1

SOAT1

47

bone morphogenetic protein 4

BMP4

48

camp-dependent protein kinase inhibitor alpha

PKIA

49

ecto-nox disulfide-thiol exchanger 2

ENOX2

50

glutamylaminopeptidase

ENPEP