From: RETRACTED ARTICLE: Suppression of NF-κB signaling by ECN in an arthritic model of inflammation
Ligand-protein interaction | Binding energy (Kcal/mol) | Hydrogen bonds | Hydrogen bond amino acids | Hydrophobic interactions |
---|---|---|---|---|
ECN-JNK | −6.0 | 1 | Arg25 | Leu363, Leu23, Lys24, Asn9, Ala510 |
ECN-NF-κB | −6.0 | 3 | His58, Ser112, Thr60 | Ile110 |
ECN-COX-2 | −7.4 | 2 | His2212, Asn2382 | Phe2210, His2207, Val2442, Ala2450, His2388, His2386, Ala2446 |
ECN-TNF-α | −8.1 | 1 | Tyr151 | Leu57, Tyr59, Tyr119 |