Table 3 Intersection target prediction between active components and disease
Number | Gene symbol | Target protein | Uniprot ID |
|---|---|---|---|
1 | ABL1 | Tyrosine-protein kinase ABL1 | P00519 |
2 | ACE | Angiotensin-converting enzyme | P12821 |
3 | ACVRL1 | Serine/threonine-protein kinase receptor R3 | P37023 |
4 | AKT1 | RAC-alpha serine/threonine-protein kinase | P31749 |
5 | APEX1 | NA-(apurinic or apyrimidinic site) endonuclease | P27695 |
6 | APP | Amyloid-beta precursor protein | P05067 |
7 | ATR | Serine/threonine-protein kinase ATR | Q13535 |
8 | AVPR2 | Vasopressin V2 receptor | P30518 |
9 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | P05093 |
10 | CYP19A1 | Aromatase | P11511 |
11 | ELANE | Neutrophil elastase | P08246 |
12 | ESR1 | Estrogen receptor | P03372 |
13 | F2 | Prothrombin | P00734 |
14 | FGFR1 | Fibroblast growth factor receptor 1 | P11362 |
15 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | P36888 |
16 | FLT4 | Vascular endothelial growth factor receptor 3 | P35916 |
17 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 |
18 | HTR2A | 5-hydroxytryptamine receptor 2A | P28223 |
19 | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic | O75874 |
20 | INSR | Insulin receptor | P06213 |
21 | JUN | Transcription factor AP-1 | P05412 |
22 | MAPK8 | Mitogen-activated protein kinase 8 | P45983 |
23 | MAPT | Microtubule-associated protein tau | P10636 |
24 | MET | Hepatocyte growth factor receptor | P08581 |
25 | MMP2 | 72 kDa type IV collagenase | P08253 |
26 | MPO | Myeloperoxidase | P05164 |
27 | NOS2 | Nitric oxide synthase, inducible | P35228 |
28 | NQO1 | NAD(P)H dehydrogenase [quinone] 1 | P15559 |
29 | PDGFRA | Platelet-derived growth factor receptor alpha | P16234 |
30 | PDGFRB | Platelet-derived growth factor receptor beta | P09619 |
31 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | P42336 |
32 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | O00329 |
33 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | P27986 |
34 | PTGS2 | Prostaglandin G/H synthase 2 | P35354 |
35 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | P07949 |
36 | SLC22A12 | Solute carrier family 22 member 12 | Q96S37 |
37 | SLC6A4 | Sodium-dependent serotonin transporter | P31645 |
38 | STS | Steryl-sulfatase | P08842 |
39 | TERT | Telomerase reverse transcriptase | O14746 |
40 | TGFB1 | Transforming growth factor beta-1 proprotein | P01137 |
41 | TTR | Transthyretin | P02766 |
42 | TYR | Tyrosinase | P14679 |
43 | XDH | Xanthine dehydrogenase/oxidase | P47989 |