Table 1 Enrichment analysis of KEGG pathways related to obesity or estrogen through the targets of compounds of Cordyceps militaris
Term | Overlap | Rank | P-value (adjusted) | Odd ratio | Combined Score | Genes |
|---|---|---|---|---|---|---|
Insulin signaling pathway | 6/137 | 28/192 | 0.0007 | 8.87 | 81.73 | PRKCI; MAPK1; PYGM; PRKCZ; ACACB; MAPK3 |
PI3K–Akt signaling pathway | 7/354 | 54/192 | 0.0109 | 3.90 | 22.54 | CASP9; HSP90AA1; BDNF; HGF; MAPK1; TLR4; MAPK3 |
MAPK signaling pathway | 6/295 | 60/192 | 0.0168 | 3.99 | 20.88 | BDNF; HGF; IL1B; CASP3; MAPK1; MAPK3 |
Estrogen signaling pathway | 4/137 | 65/192 | 0.0191 | 5.71 | 28.76 | HSP90AA1; MAPK1; MMP9; MAPK3 |
Insulin resistance | 3/108 | 89/192 | 0.0445 | 5.38 | 20.86 | PYGM; PRKCZ; ACACB |