Fig. 4
S. officinalis extracts attenuation of ROS release by human brain microvascular endothelial cells after 24-h treatment with H2O2. Levels of ROS released in human brain microvascular endothelial culture media after 24 h treatment with 1, 5, 20 and 50 μg/mL of S. officinalis extract and in the presence or absence of 1 mM of H2O2. All values are mean ± SEM (n = 8, in each treated cell group). See inset keys for sage dose. Statistical analysis were performed using one-way ANOVA test flowed by Dunnett’s multiple comparison test. Statistical significance is shown as * p < 0.05, ** p < 0.01 and *** p < 0.001