Histopathological Changes | Control | CCl4 | Sp150 | Sp300 | Silymarin |
---|---|---|---|---|---|
Centrilobular necrosis | 0 ± 0 | 74.17 ± 9.97*** | 27.76 ± 4.28### | 15.78 ± 6.54### | 46.66 ± 9.49### |
Ballooning degeneration | 0 ± 0 | 79.16 ± 8.08*** | 47.23 ± 4.28### | 5.55 ± 3.8### | 15 ± 10.87### |
Fatty change | 0.83 ± 2.62 | 34.99 ± 11.64*** | 18.06 ± 6.27### | 4.15 ± 3.5## | 18.34 ± 6.98## |
Inflammatory cell infiltration | 2.49 ± 4 | 68.34 ± 6.58*** | 41.66 ± 7.46### | 20.85 ± 4.54### | 43.34 ± 6.98### |
Focal necrosis | 1.66 ± 3.49 | 67.5 ± 9.17*** | 29.15 ± 4.54### | 11.1 ± 4.33### | 45 ± 7.46### |
Parenchymal architecture disruption | 1.66 ± 3.49 | 68.33 ± 7.67*** | 38.88 ± 6.82### | 19.45 ± 6.8### | 36.66 ± 9.51### |