In vivo assessment of the antimalarial activity and acute oral toxicity of an ethanolic seed extract of Spondias pinnata (L.f.) Kurz

Table 8 Effect of ethanolic S. pinnata seed extract on kidney and liver functions in the acute toxicity test

Parameter	Untreated control	Negative control	2,000 mg/kg extract
Liver function test
AST (U/L)	86.80 ± 5.15	87.50 ± 2.50	83.40 ± 5.64
ALT (U/L)	35.36 ± 3.30	37.50 ± 3.20	36.20 ± 4.02
ALP (U/L)	85.90 ± 4.09	86.03 ± 3.23	83.40 ± 2.07
Kidney function test
BUN (mg/dL)	25.36 ± 2.88	27.72 ± 1.30^b	24.36 ± 0.68^a
Creatinine (mg/dL)	0.64 ± 0.03	0.66 ± 0.04	0.63 ± 0.02

Data are presented as the means ± SDs (n = 5 per group)
^acompared to the negative control group, and ^bcompared to the treatment group that received a dose of 2,000 mg/kg body weight

ISSN: 2662-7671