In vivo assessment of the antimalarial activity and acute oral toxicity of an ethanolic seed extract of Spondias pinnata (L.f.) Kurz

Table 5 Effect of the ethanolic S. pinnata seed extract on parasite levels and parasite suppression during the prophylactic test

Group	Dose (mg/kg)	% Parasitemia	% Suppression	Mean survival time (days)
Negative control	-	20.39 ± 0.96^b,c,d,e,f	-	11.60 ± 4.59
Positive control	6	13.47 ± 0.62^a^,^c^,^d^,^e	33.93 ± 3.03^a^,^c^,^d^,^e	16.20 ± 4.79
S. pinnata extract	250	17.67 ± 0.81^a^,^b^,^d^,^e^,^f	13.35 ± 3.99^a^,^b^,^d^,^e^,^f	11.40 ± 1.52
	500	15.29 ± 1.03^a^,^b^,^c^,^f	24.99 ± 5.05^a^,^b^,^c^,^f	14.60 ± 3.91
	600	15.19 ± 0.53^a^,^b^,^c^,^f	25.49 ± 2.58^a^,^b^,^c^,^f	14.40 ± 4.04
	800	14.06 ± 0.79^a^,^c^,^d^,^e	31.06 ± 3.87^a^,^c^,^d^,e	15.20 ± 3.90

Data are presented as the means ± SDs (n = 5 per group)
^aCompared with the negative control group receiving a mixture of 7% Tween 80 and 3% ethanol in distilled water, ^bcompared with the positive control group receiving 6 mg/kg artesunate, ^ccompared with 250 mg/kg extract, ^dcompared with 500 mg/kg extract, ^ecompared with 600 mg/kg extract, and ^fcompared with 800 mg/kg extract

ISSN: 2662-7671