In vivo assessment of the antimalarial activity and acute oral toxicity of an ethanolic seed extract of Spondias pinnata (L.f.) Kurz

Table 4 Effect of the ethanolic S. pinnata seed extract on the parasite level and parasite suppression in the curative activity test

Group	Dose (mg/kg)	% Parasitemia	% Suppression	Mean survival time (days)
Negative control	-	32.94 ± 2.98^b,c,d,e,f	-	10.00 ± 3.29
Positive control	6	4.71 ± 0.92^a^,^c^,^d^,^e^,^f	85.71 ± 2.79^a^,^c^,^d^,^e^,^f	16.60 ± 1.85^c,d
S. pinnata extract	250	27.32 ± 1.14^a^,^b^,^d^,^e^,^f	17.05 ± 3.47^a^,^b^,^d^,^e^,^f	7.20 ± 1.10^b
	500	18.96 ± 1.19^a^,^b^,^c^,^e^,^f	42.46 ± 3.62^a^,^b^,^c^,^e^,^f	8.20 ± 1.30^b
	600	14.23 ± 1.22^a^,^b^,^c^,^d	56.79 ± 3.70^a^,^b^,^c^,^d	9.60 ± 1.14
	800	15.96 ± 1.10^a^,^b^,^c^,^d	51.54 ± 3.33^a^,^b^,^c^,^d	13.20 ± 6.98

Data are presented as the means ± SDs (n = 5 per group)
^aCompared with the negative control group receiving a mixture of 7% Tween 80 and 3% ethanol in distilled water, ^bcompared with the positive control group receiving 6 mg/kg artesunate, ^ccompared with 250 mg/kg extract, ^dcompared with 500 mg/kg extract, ^ecompared with 600 mg/kg extract, and ^fcompared with 800 mg/kg extract

ISSN: 2662-7671