In vivo assessment of the antimalarial activity and acute oral toxicity of an ethanolic seed extract of Spondias pinnata (L.f.) Kurz

Table 3 Effect of the ethanolic S. pinnata seed extract on parasite level, parasite suppression, and mean survival time during the 4-day suppressive test

Group	Dose (mg/kg)	% Parasitemia	% Suppression	Mean survival time (days)
Negative control	-	33.44 ± 0.18^b,c,d,e,f	-	9.60 ± 0.61^b,f
Positive control	6	1.10 ± 0.21^a^,^c^,d,e,f	96.72 ± 0.62^a^,^c^,d,e,f	18.40 ± 0.88^a^,^c^,d
S. pinnata extract	250	25.77 ± 0.34^a^,^b^,d,e,f	22.94 ± 1.02^a^,^b^,d,e,f	10.20 ± 0.92^a^,f
	500	17.05 ± 1.04^a^,^b^,^c^,e,f	49.01 ± 3.10^a^,^b^,^c^,e,f	13.20 ± 1.99^b
	600	13.15 ± 1.11^a^,^b^,^c^,d,f	60.67 ± 3.32^a^,^b^,^c^,d,f	14.00 ± 2.05
	800	11.10 ± 1.34^a^,^b^,^c^,d,e	66.82 ± 4.00^a^,^b^,^c^,d,e	16.20 ± 2.03^a^,^c

Data are presented as the means ± SDs (n = 5 per group)
^aCompared with the negative control group receiving a mixture of 7% Tween 80 and 3% ethanol in distilled water, ^bcompared with the positive control group receiving 6 mg/kg artesunate, ^ccompared with 250 mg/kg extract, ^dcompared with 500 mg/kg extract, ^ecompared with 600 mg/kg extract, and ^fcompared with 800 mg/kg extract

ISSN: 2662-7671